D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys.
Identifieur interne : 003625 ( Main/Exploration ); précédent : 003624; suivant : 003626D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys.
Auteurs : R. Grondin [Canada] ; V D Doan ; L. Grégoire ; P J BédardSource :
- Neurology [ 0028-3878 ] ; 1999.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects), Animals, Behavior, Animal (drug effects), Female, Levodopa (therapeutic use), Locomotion (drug effects), Macaca fascicularis, Movement Disorders (drug therapy), Parkinson Disease, Secondary (chemically induced), Receptors, Dopamine D1 (antagonists & inhibitors).
- MESH :
- chemical , adverse effects : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemical , antagonists & inhibitors : Receptors, Dopamine D1.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Behavior, Animal, Locomotion.
- drug therapy : Movement Disorders.
- chemical , therapeutic use : Levodopa.
- Animals, Female, Macaca fascicularis.
Abstract
To determine whether dopamine (DA) D1 or DA D2 receptors are associated predominantly with the antiparkinsonian versus the dyskinetic effect of levodopa.
PubMed: 10078726
Affiliations:
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Le document en format XML
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Grondin</name><affiliation wicri:level="1"><nlm:affiliation>CHUL Research Centre, Department of Medicine, Faculty of Medicine, Laval University, Ste-Foy (Quebec), Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>CHUL Research Centre, Department of Medicine, Faculty of Medicine, Laval University, Ste-Foy (Quebec)</wicri:regionArea><wicri:noRegion>Ste-Foy (Quebec)</wicri:noRegion></affiliation></author><author><name sortKey="Doan, V D" sort="Doan, V D" uniqKey="Doan V" first="V D" last="Doan">V D Doan</name></author><author><name sortKey="Gregoire, L" sort="Gregoire, L" uniqKey="Gregoire L" first="L" last="Grégoire">L. Grégoire</name></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects)</term><term>Animals</term><term>Behavior, Animal (drug effects)</term><term>Female</term><term>Levodopa (therapeutic use)</term><term>Locomotion (drug effects)</term><term>Macaca fascicularis</term><term>Movement Disorders (drug therapy)</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Receptors, Dopamine D1 (antagonists & inhibitors)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Locomotion</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Macaca fascicularis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether dopamine (DA) D1 or DA D2 receptors are associated predominantly with the antiparkinsonian versus the dyskinetic effect of levodopa.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name><name sortKey="Doan, V D" sort="Doan, V D" uniqKey="Doan V" first="V D" last="Doan">V D Doan</name><name sortKey="Gregoire, L" sort="Gregoire, L" uniqKey="Gregoire L" first="L" last="Grégoire">L. Grégoire</name></noCountry><country name="Canada"><noRegion><name sortKey="Grondin, R" sort="Grondin, R" uniqKey="Grondin R" first="R" last="Grondin">R. Grondin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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